张伟

2021-01-30 13:31:15 Macao Young Scholars Program 2021 26
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张伟
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Macao Young Scholars Program 2021

Supervisors

 

Ref. No.: MYSP-2021-072

Section 1: Personal Particulars

*Name in Chinese:

张伟

*Name in English:

Wei Zhang

*Academic Rank:

Associate Professor

*Telephone:

00853-63869635

Fax:


*E-mail: 

wzhang@must.edu.mo

Mailing Address:

新城市花园15座21楼E室

*Institution:

Macau University of Science and Technology

*Department:

MUST-SKL of Quality Research in Chinese Medicine

Administrative Post:


Personal Webpage:

https://www.must.edu.mo/images/SKL/files/ZhangWei_TC_v180821.pdf

 



Research Project provided for Macao Youth Scholars Program:

*Project Name in Chinese:

多组学技术开展川贝母等六种中药的多维度质量控制研究

*Project Name in English:

Study on multi-dimensional quality control of six Chinese herbal Medicines through multi-omics technologies

*Academic Discipline (Primary):

1008  中药学

Academic Discipline (Secondary, for reference):

1007  药学

Special requirement for the postdoctoral fellow candidates:


Academic Qualifications:

Postdoctoral training: Aug.2008-2012 Pharmacology Department, School of Medicine, Yale University,  Ph.D. 2003- 2008, Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education) & Center for instrumental analysis, China Pharmaceut

Professional Accomplishments, honors, awards and patents:

Dr. Zhang’s research fields include phytochemical analysis of traditional Chinese medicines by modern instruments together with chemometric methods and the application of nanomaterials in analytical chemistry. His team has also discovered several nucleotide biomarkers and mechanism based combination therapy strategies for overcoming nucleotide analogs resistance for targeted therapies. He has published over 80 peer-reviewed SCI journals including Science Translational Medicine, Analytical Chemistry, Biochemical Pharmacology, Analyst, Analytical and Bioanalytical Chemistry, Analytica Chimica Acta, Talanta, Advanced Energy Materials and etc. Dr. Zhang obtained 6 Australia patents with the works related to the discovery of novel nucleotide biomarkers, novel nucleoside analogue enhancer for treatment of cancer and Non-alcoholic fatty liver disease.

 

Section 2: Research Interests and Grants

Major Research Interests:

1、Use of chemometrics methods to deal with all steps of analytical procedures;

2、Pharmaceutical Analysis (Chemical and Instrumental Analysis);

3、Pharmacokinetic and metabolism study of chemical drugs and traditional Chinesemedicines (TCM);

4、Phytochemical analysis and quality assessment of traditional Chinese medicines (TCM)based modern instruments;

Number of Current PhD Students:

3

Number of PhD Trained:

5

Number of Postdoctoral Fellows Supervised:

2

*Research Grants for MYSP: (Please include project titles, funding sources, reference number, funding amounts and duration)

1.     Integrative patterns of efficient components recognition of Aloe based on Wnt/β-Catenin signaling pathway, Macau Science and Technology Development Fund, MOP 1,112,100,2019-2022

2.     Synergistic antitumor activity of 5-fluorouracil in colorectal cancer based on the targeted-regulation of nucleotide metabolism, Macau Science and Technology Development Fund, MOP 1,434,400,2019-2022

3.     Study on multi-dimensional quality control of six Chinese herbal Medicines by combining artificial intelligence and multi-omics technologies,Macau Science and Technology Development Fund, MOP 8,000,000,2019-2022

4.     Living single-cell analyzer based on light beam control and manipulation, 61827819, National Natural Science Foundation of China,RMB 7,769,000, 2019/1-2023/12